ABCA1 and HDL
| Autor: | Silvia, Castiglioni, Matteo, Monti, Lorenzo, Arnaboldi, Monica, Canavesi, Giuditta, Ainis Buscherini, Laura, Calabresi, Alberto, Corsini, Stefano, Bellosta |
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| Rok vydání: | 2017 |
| Předmět: |
Male
Mice Knockout Genotype Cholesterol HDL Myocytes Smooth Muscle Kruppel-Like Transcription Factors Nuclear Proteins Muscle Smooth Vascular Mice Inbred C57BL Kruppel-Like Factor 4 MicroRNAs Cholesterol Phenotype Gene Expression Regulation Cell Transdifferentiation Trans-Activators Animals Female Biomarkers Cells Cultured ATP Binding Cassette Transporter 1 ATP Binding Cassette Transporter Subfamily G Member 1 Foam Cells Signal Transduction |
| Zdroj: | Atherosclerosis. 266 |
| ISSN: | 1879-1484 |
| Popis: | Cholesterol-loaded smooth muscle cells (SMCs) modify their phenotypic behavior becoming foam cells. To characterize the role of ABCA1 and HDLSMCs, isolated from the aortae of wild-type (WT) and Abca1 knock-out (KO) mice, were cholesterol-loaded using a "water-soluble cholesterol''.Cholesterol loading downregulates the expression of Acta2 and calponin (SMC markers), and increases the expression of Mac-2, CD11b and MHCII (inflammation-related genes and surface antigens) and Abca1, Abcg1. HDLOur results indicate that HDL |
| Databáze: | OpenAIRE |
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