Chromatographic separation and assignment of absolute configuration of hydroxywarfarin isomers

Autor:	Erik L, Regalado, Edward C, Sherer, Mitchell D, Green, Derek W, Hendersonl, R, Thomas Williamson, Leo A, Joyce, Christopher J, Welch
Rok vydání:	2013
Předmět:	Chromatography Isomerism Molecular Structure Circular Dichroism Microsomes Liver Humans Computer Simulation Stereoisomerism Warfarin Hydroxylation
Zdroj:	Chirality. 26(2)
ISSN:	1520-636X
Popis:	The absolute configuration of several hydroxywarfarin isomers was assigned using a comparison of elution order on chiral stationary phases, optical rotation, and circular dichroism (CD) spectra, with confirmation of assignments made by comparison between experimental and calculated CD spectra and selective synthesis of hydroxywarfarin isomers from enantiopure warfarin using human liver microsomes.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::99c139e2181b88b38b3384333325abf4 https://pubmed.ncbi.nlm.nih.gov/24339228 Zobrazit plný text záznamu Plný text