Molecular Analysis in Factor XI Deficiency
| Autor: | K M, Johnson, J H, McVey |
|---|---|
| Rok vydání: | 2011 |
| Zdroj: | Methods in molecular medicine. 31 |
| ISSN: | 1543-1894 |
| Popis: | Factor XI (FXI) is the zymogen precursor of an active serine protease that participates in the contact phase of coagulation. Synthesized in the liver, it circulates in the plasma in a noncovalent complex with high molecular weight kininogen (1) at a normal concentration of 5 μg/mL. (For clinical purposes, the normal range is defined as 50-150 U/dL) (2). FXI circulates as a homodimeric glycoprotein with a mass of 160 kDa. |
| Databáze: | OpenAIRE |
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