| Autor: |
Philip S, Boyd, Johannes, Breitling, Ferdinand, Zimmermann, Andreas, Korzowski, Moritz, Zaiss, Patrick, Schuenke, Nina, Weinfurtner, Heinz-Peter, Schlemmer, Mark E, Ladd, Peter, Bachert, Daniel, Paech, Steffen, Goerke |
| Rok vydání: |
2019 |
| Předmět: |
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| Zdroj: |
Magnetic resonance in medicineREFERENCES. 84(1) |
| ISSN: |
1522-2594 |
| Popis: |
Dynamic glucose-enhanced (DGE)-MRI based on chemical exchange-sensitive MRI, that is, glucoCEST and gluco-chemical exchange-sensitive spin-lock (glucoCESL), is intrinsically prone to motion-induced artifacts because the final DGE contrast relies on the difference of images, which were acquired with a time gap of several mins. In this study, identification of different types of motion-induced artifacts led to the development of a 3D acquisition protocol for DGE examinations in the human brain at 7 T with improved robustness in the presence of subject motion.DGE-MRI was realized by the chemical exchange-sensitive spin-lock approach based either on relaxation rate in the rotating frame (REven after coregistration, significant motion-induced artifacts remained in the DGE contrast based on RThe presented 3D acquisition protocol enables DGE-MRI examinations in the human brain with improved robustness against motion-induced artifacts. Correction of motion-induced artifacts is of high importance for DGE-MRI in clinical studies where an unambiguous assignment of contrast changes due to an actual change in local glucose concentration is a prerequisite. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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