| Autor: |
Chinami, Araki, Nobuhide, Hayashi, Masako, Moriyama, Sahoko, Morinobu, Masahiko, Mukai, Masahiro, Koshiba, Seiji, Kawano, Shunichi, Kumagai |
| Rok vydání: |
2005 |
| Předmět: |
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| Zdroj: |
Rinsho byori. The Japanese journal of clinical pathology. 52(12) |
| ISSN: |
0047-1860 |
| Popis: |
Rheumatoid factor (RF) has been commonly used as a marker of rheumatoid arthritis (RA). RF can be detected in 60-80% of RA patients, but the specificity is low against other rheumatic diseases patients. We evaluated the diagnostic accuracy of anti-cyclic citrullinated peptide antibody (anti-CCP), a new diagnostic test for RA. Anti-CCP demonstrated higher sensitivity (81.0%) and specificity (92.4%). By the receiver operating characteristic (ROC) curve analysis, anti-CCP was superior to other markers (ie. RF, CARF, IgG-RF, and MMP-3). In early RA patients (RA patients who had had disease symptoms for2 years), sensitivity was 68.8%. Positivities of anti-CCP in RA patients became higher as the advance of stage defined by the Steinbrocker classification. We concluded that anti-CCP is a very valuable tool for the diagnosis of RA. Moreover, anti-CCP is a useful for finding RA of recent onset. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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