[The enkephalinase mechanisms of the resistance and tolerance to the analgesic effect of morphine in rats. Differences in the effects of the action of D-phenylalanine in morphine-sensitive, morphine-tolerant and morphine-resistant rats]

Autor:	S V, Litvinova, A Iu, Kozlov, L V, Kaliuzhnyĭ
Rok vydání:	1993
Předmět:	Male Time Factors Dose-Response Relationship Drug Morphine Phenylalanine Drug Resistance Animals Pain Neprilysin Drug Tolerance Analgesia Rats Wistar Rats
Zdroj:	Biulleten' eksperimental'noi biologii i meditsiny. 116(7)
ISSN:	0365-9615
Popis:	In morphine-sensitive (s.c. 1.5 mg/kg) Wistar rats (60%) i.p. inoculation of 300-600 mg/kg d-Phenylalanine (d-Pha) did not change the nociception (tail-flick test), but in morphine-resistant rats (40%) evoked a dose-dependent analgetic effect. In morphine-sensitive rats (40%) chronic morphine administration induced the tolerance and d-Pha injection evoked analgetic effect. Morphine injection just after d-Pha analgesia was over evoked analgetic effect in morphine-resistant and -tolerant rats. It is suggested that morphine-resistant rats have a congenital and morphine-tolerant rats an acquired high level of enkephalinase activity which blocked the morphine analgetic action.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::98be7ddf7ea10e3faa9a039f9a9f81f3 https://pubmed.ncbi.nlm.nih.gov/8400183 Zobrazit plný text záznamu