| Autor: |
P G, Sala, S, Mazzolini, E, Tonutti, C, Crucil, E, Pitzus, M, Bramezza |
| Rok vydání: |
1987 |
| Předmět: |
|
| Zdroj: |
Bollettino dell'Istituto sieroterapico milanese. 66(1) |
| ISSN: |
0021-2547 |
| Popis: |
Sera from 55 patients with positivity for anti-HTLV III antibodies, including 24 "healthy" subjects, 29 LAS and 2 AIDS, were examined by means of high resolution agarose gel electrophoresis and immunofixation, in order to evaluate the occurrence of monoclonal-oligoclonal immunoglobulin patterns. Monoclonal-oligoclonal immunoglobulins were found in 20.8% of "healthy" subjects and in 72.4% of LAS patients. Furthermore, a lower but significant prevalence of monoclonal-oligoclonal immunoglobulins was found in a control group including patients with high-titre positivity for anti-CMV and anti-EBV antibodies. Considering the consistent association between EBV-CMV and HTLV III infection, it is concluded that at least a part of monoclonal-oligoclonal immunoglobulins found in LAS-AIDS patients are likely to be induced by these associated viral infections. On the other hand, the finding of monoclonal-oligoclonal immunoglobulins in "healthy" HTLV III-positive subjects points out a possible direct stimulatory effect of HTLV III on B-cell lineage. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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