Azathioprine or methotrexate in the treatment of patients with steroid-dependent or steroid-resistant ulcerative colitis: results of an open-label study on efficacy and tolerability in inducing and maintaining remission

Autor:	O A, Paoluzi, R, Pica, A, Marcheggiano, P, Crispino, F, Iacopini, C, Iannoni, M, Rivera, P, Paoluzi
Rok vydání:	2002
Předmět:	Adult Male Remission Induction Anti-Inflammatory Agents Drug Resistance Middle Aged Drug Administration Schedule Methotrexate Treatment Outcome Azathioprine Humans Prednisone Colitis Ulcerative Female Single-Blind Method Immunosuppressive Agents Aged Follow-Up Studies
Zdroj:	Alimentary pharmacologytherapeutics. 16(10)
ISSN:	0269-2813
Popis:	The role of azathioprine and methotrexate in inducing and maintaining remission in patients with ulcerative colitis is still controversial.To evaluate the efficacy and tolerability of these two drugs in a series of patients with steroid-dependent or steroid-resistant active ulcerative colitis.Forty-two patients were treated with a daily dose of azathioprine (2 mg/kg) and, if intolerant or not responding, with methotrexate (12.5 mg/week intramuscularly), and their efficacy was established by clinical, endoscopic and histological examinations at 6 months. Patients achieving clinical remission continued with treatment and were followed up.Of the 42 patients on azathioprine, 10 experienced early side-effects requiring withdrawal from treatment, 22 (69%) achieved complete remission, six (19%) achieved improvement and four (12%) obtained no substantial benefit. Methotrexate, administered to eight patients intolerant to and two patients resistant to azathioprine, induced complete remission in six patients (60%) and improvement in four (40%). During follow-up, a larger number of patients on azathioprine relapsed in comparison with patients on methotrexate [16/28 (57%) vs. 2/10 (20%), respectively; P0.05]. Only minor side-effects were observed on both treatments.Azathioprine is effective in patients with steroid-dependent or steroid-resistant ulcerative colitis. Methotrexate seems to be a good alternative in patients intolerant to or not responding to azathioprine.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::9887bf16591bdb5b545068b48ec1f21d https://pubmed.ncbi.nlm.nih.gov/12562464 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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