| Autor: |
Roman C, Sarott, Alexander E G, Viray, Patrick, Pfaff, Anastasiia, Sadybekov, Gabriela, Rajic, Vsevolod, Katritch, Erick M, Carreira, James A, Frank |
| Rok vydání: |
2021 |
| Předmět: |
|
| Zdroj: |
Journal of the American Chemical Society. 143(2) |
| ISSN: |
1520-5126 |
| Popis: |
Cannabinoid receptor 2 (CB2) is a promising target for the treatment of neuroinflammation and other diseases. However, a lack of understanding of its complex signaling in cells and tissues complicates the therapeutic exploitation of CB2 as a drug target. We show for the first time that benchmark CB2 agonist HU308 increases cytosolic Ca |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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