| Autor: |
Angela L, Woods, David, Parker, Meir M, Glick, Yunshan, Peng, Francois, Lenoir, Evan, Mulligan, Vincent, Yu, Grazia, Piizzi, Troy, Lister, Maria-Dawn, Lilly, JoAnn, Dzink-Fox, Johanna M, Jansen, Neil S, Ryder, Charles R, Dean, Thomas M, Smith |
| Rok vydání: |
2021 |
| Zdroj: |
ACS omega. 7(6) |
| ISSN: |
2470-1343 |
| Popis: |
The continuing emergence of antibacterial resistance reduces the effectiveness of antibiotics and drives an ongoing search for effective replacements. Screening compound libraries for antibacterial activity in standard growth media has been extensively explored and may be showing diminishing returns. Inhibition of bacterial targets that are selectively important under in vivo (infection) conditions and, therefore, would be missed by conventional in vitro screens might be an alternative. Surrogate host models of infection, however, are often not suitable for high-throughput screens. Here, we adapted a medium-throughput |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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