Hormonally regulated alpha(4)beta(2)delta GABA(A) receptors are a target for alcohol
| Autor: | Inger, Sundstrom-Poromaa, Deborah H, Smith, Qi Hua, Gong, Thomas N, Sabado, Xinshe, Li, Adam, Light, Martin, Wiedmann, Keith, Williams, Sheryl S, Smith |
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| Rok vydání: | 2002 |
| Předmět: |
Patch-Clamp Techniques
Dose-Response Relationship Drug Ethanol In Vitro Techniques Receptors GABA-A Transfection Hippocampus Recombinant Proteins Article Rats Premenstrual Syndrome Disease Models Animal Protein Subunits Xenopus laevis Chlorides Oocytes Animals Female RNA Messenger Ion Channel Gating Progesterone gamma-Aminobutyric Acid |
| Zdroj: | Nature neuroscience. 5(8) |
| ISSN: | 1097-6256 |
| Popis: | Here we report that low concentrations of alcohol (1-3 mM) increased Cl(-) currents gated by a recombinant GABA(A) receptor, alpha(4)beta(2)delta, by 40-50% in Xenopus laevis oocytes. We also found greater hippocampal expression of receptors containing alpha(4) and delta subunits, using a rat model of premenstrual syndrome (PMS) in which 1-3 mM alcohol preferentially enhanced GABA-gated currents, and low doses of alcohol attenuated anxiety and behavioral reactivity. The alcohol sensitivity of delta-containing receptors may underlie the reinforcing effects of alcohol during PMS, when eye saccade responses to low doses of alcohol are increased. |
| Databáze: | OpenAIRE |
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