[Inflammatory ointment from shea butter and hydro-alcoholic extract of Khaya senegalensis barks (Cailcederat)]
| Autor: | O, Thioune, D, Ahodikpe, M, Dieng, A B, Diop, S, Ngom, I, Lo |
|---|---|
| Jazyk: | francouzština |
| Rok vydání: | 2005 |
| Předmět: |
Lanolin
Petrolatum Croton Oil Plant Extracts Indomethacin Anti-Inflammatory Agents Drug Evaluation Preclinical Oleic Acids Administration Cutaneous Dexamethasone Senegal Excipients Ointments Disease Models Animal Mice Plant Bark Animals Edema Plant Oils Meliaceae Ear Diseases Medicine African Traditional Phytotherapy |
| Zdroj: | Dakar medical. 45(2) |
| ISSN: | 0049-1101 |
| Popis: | In a former study, it was proved that the alcoholic solution of hydro-alcoholic extract of Khaya senegalensis barks had an anti-inflammatory activity on animals after a local application. In this work, ointments made from the same extract and three different excipients (vaseline, lanoline and shea butter (crude and refined)) have been prepared and tested by the method of the croton oil inhibited ear oedema. Results showed inhibition percentages of the ear oedema of 58.8%, 66.7% and 75.4% when the hydro-alcoholic extract was tested at respective doses of 1%, 2% and 3% in shea butter. The two other excipients, (vaceline and Lanoline) tested at the dose of 3% showed between 52% and 58% of inhibitions. The interest of this study was to demonstrate the possibility to maintain the anti-inflammatory activity of Khaya senegalensis barks by using them in a galenic form, easy to prepare and which is, in addition, more adapted than the extract to possible clinical trials. |
| Databáze: | OpenAIRE |
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