Low protein expression of MET in ER-positive and HER2-positive breast cancer
| Autor: | Flora, Zagouri, Anita, Brandstetter, Dimitrios, Moussiolis, Dimosthenis, Chrysikos, Constantine, Dimitrakakis, Alexandra, Tsigginou, Spyros, Marinopoulos, George C, Zografos, Theodoros N, Sergentanis, Meletios-Athanassios, Dimopoulos, Martin, Filipits |
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| Rok vydání: | 2014 |
| Předmět: |
Adult
Aged 80 and over Receptor ErbB-2 Carcinoma Ductal Breast Breast Neoplasms Middle Aged Proto-Oncogene Proteins c-met Prognosis Immunoenzyme Techniques Carcinoma Lobular Receptors Estrogen Biomarkers Tumor Humans Female Neoplasm Grading Receptors Progesterone Aged Follow-Up Studies Neoplasm Staging |
| Zdroj: | Anticancer research. 34(3) |
| ISSN: | 1791-7530 |
| Popis: | The mesenchymal-epithelial transition factor (MET) is a receptor tyrosine kinase that plays a key role in cell survival, growth, angiogenesis and metastasis. Because its expression is frequently altered in tumors, MET is currently under investigation as a potential target for anticancer therapy. The purpose of the present study was to determine the prognostic value of tumor MET expression levels in patients with estrogen receptor (ER)-positive and human epidermal growth factor receptor 2 (HER2)-positive breast cancer, in order to strengthen the rationale for targeted therapy using MET inhibitors in this breast cancer subpopulation.We determined the expression of MET in formalin-fixed paraffin-embedded surgical specimens of ER- and HER2-positive breast cancer by immunohistochemistry.Comparisons of MET expression with clinical parameters, including survival of the patients, were performed with MET expression as a dichotomized variable classified as high or low. Out of 78 tumors, 3 (3.8%) showed high MET expression. The analysis examining the association between MET and survival did not yield any statistically significant result regarding overall survival or disease-free survival.ER- and HER2-positive breast carcinomas do not exhibit high MET expression. This null finding, the first to be reported in the literature, is of great importance, since it indicates that this sub-group population is not proper candidate for clinical trials with MET inhibitors. |
| Databáze: | OpenAIRE |
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