| Autor: |
Ha Yin, Lee, Yoko, Itahana, Stefan, Schuechner, Masahiro, Fukuda, H Shawn, Je, Egon, Ogris, David M, Virshup, Koji, Itahana |
| Rok vydání: |
2018 |
| Předmět: |
|
| Zdroj: |
Science signaling. 11(512) |
| ISSN: |
1937-9145 |
| Popis: |
Cancer cells increase glucose metabolism to support aerobic glycolysis. However, only some cancer cells are acutely sensitive to glucose withdrawal, and the underlying mechanism of this selective sensitivity is unclear. We showed that glucose deprivation initiates a cell death pathway in cancer cells that is dependent on the kinase RIPK1. Glucose withdrawal triggered rapid plasma membrane depolarization and an influx of extracellular calcium into the cell through the L-type calcium channel Ca |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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