[Intercellular information transfer in the process of immunogenesis. VI. The induction of antiphage antibody synthesis in the cells of rat transplantable lymphosarcoma under the influence of splenic RNA from rats and mice immunized with phage T2]

Autor:	O N, Pogodina, N N, Aksenova, M L, Figel'man, V Ia, Fel'
Rok vydání:	1979
Předmět:	Immunity Cellular Time Factors Antibodies Neoplasm Lymphoma Non-Hodgkin Neoplasms Experimental Antibodies Viral Coliphages Rats Mice Bacteriolysis Antibody Formation Escherichia coli Animals RNA Immunization Immunity Maternally-Acquired Neoplasm Transplantation Spleen
Zdroj:	Tsitologiia. 21(4)
ISSN:	0041-3771
Popis:	It has been proved that nuclear and cytoplasmic RNAs, isolated from spleens of T2 phage immunized rats and mice, can induce T2 phage antibodies in cells of the transplantable rat lymphosarcoma. With the nuclear RNA from rat spleens, the effect is persisting in a number of subsequent cell generations. The data presented are principally in accord with results of the authors' previous studies in which lymphosarcoma cells were treated with RNA extracted from spleens of rat immunized with sheep red cells. These results well compare with the authors' earlier advanced hypothesis suggesting a possible involvement of RNA in deblockation of genes responsible for the synthesis of the antibodies in question.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::979d1aada78050e161bd90a27eb9f36c https://pubmed.ncbi.nlm.nih.gov/377738 Zobrazit plný text záznamu