The Relationship Between Asthma, Eosinophilia, and Outcomes in COVID-19 Infection
| Autor: | Ho, Kam Sing, Howell, Daniel, Rogers, Linda, Narasimhan, Bharat, Verma, Hannah, Steiger, David |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
ICU admission
chronic obstructive pulmonary disease (COPD) body mass index BMI) prevalence Charlson comorbidity index (CCI) mortality Article Asthma COVID-19 infection Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) T2 inflammation Interleukin-6 (IL-6) Coronavirus 2019 (COVID-19) C-reactive protein (CRP) eosinophilia hospitalization |
| Zdroj: | Annals of Allergy, Asthma & Immunology |
| ISSN: | 1534-4436 1081-1206 |
| Popis: | Background The impact of asthma diagnosis and asthma endotype on outcomes from COVID-19 infection remains unclear. Objective To describe the association between asthma diagnosis and endotype and clinical outcomes among patients diagnosed with COVID-19 infection. Methods Retrospective multicenter cohort study of outpatients and inpatients presenting to six hospitals in the Mount Sinai Health System New York metropolitan region between March 7 th to June 7 th , 2020, with COVID-19 infection, with and without a history of asthma. The primary outcome assessed was in-hospital mortality. Secondary outcomes included hospitalization, intensive care unit (ICU) admission, mechanical ventilation, and hospital length of stay. Outcomes were compared in patients with or without asthma using a multivariate Cox regression model. Outcomes stratified by blood eosinophilia count were also assessed. Results Of 10,523 patients diagnosed with COVID-19 infection, 4902 patients were hospitalized, and 468 had a diagnosis of asthma (4.4%). When adjusted for COVID-19 disease severity, comorbidities, and concurrent therapies, patients with asthma had a lower mortality [adjusted odds ratio (OR) 0.64 (0.53-0.77), p |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|