| Autor: |
U A, Zifko, Monika, Rupp, Sigrid, Schwarz |
| Jazyk: |
němčina |
| Rok vydání: |
2002 |
| Předmět: |
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| Zdroj: |
Wiener medizinische Wochenschrift (1946). 152(13-14) |
| ISSN: |
0043-5341 |
| Popis: |
The aim of the study is to test the tolerability and efficacy of 50 mg Sertralin in the treatment of Post-Stroke depression (PSD).Open-label, 3-months study of in- and outpatients. Evaluation of the 5-Item WHO-Wellbeing Index, the Clinical Global Impression test (CGI) and documentation of the subjective evaluation of tolerability and efficacy by patients and examining doctors.267 out of 287 patients (150 women, 137 men; mean age 68.6 +/- 12.1 years with a range from 27 to 100 years) took part in the study over a 12 months period.Eight patients had to stop the study because of side-effects. The WHO-Wellbeing Index improved from a baseline value of 26.7 +/- 17.1 to 45.0 +/- 18.3 after 4 weeks (p0.001), and to 57.2 +/- 19.5 after 12 weeks (p0.001). The CGI after 12 weeks gave evidence of an improvement in 252 patients (88%). No change of PSD was seen in 10 patients (3%), and deterioration of PSD was observed in 5 patients (2%). The duration between onset of treatment and improvement was 13.3 +/- 6 days.A single dose of 50 mg Sertralin is well tolerated in patients with PSD. The WHO-Wellbeing Index and the CGI gave evidence of significant improvement of PSD in the majority of examined patients participating in this open-label study. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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