[Successful treatment of adult Still's disease with tofacitinib in a HIV-2 positive female patient]

Autor:	P, Hoff, M, Walther, H, Wesselmann, J, Weinerth, E, Feist, S, Ohrndorf
Jazyk:	němčina
Rok vydání:	2020
Předmět:	Adult Pyrimidines Treatment Outcome Piperidines HIV-2 Humans Female HIV Infections Pyrroles Middle Aged Protein Kinase Inhibitors Still's Disease Adult-Onset
Zdroj:	Zeitschrift fur Rheumatologie. 79(10)
ISSN:	1435-1250
Popis:	A 46-year-old female patient with a known HIV-2-infection suffered from adult onset Still's disease, which was initially complicated by a macrophage activation syndrome (MAS). The required glucocorticoid treatment induced a psychosis and the patient developed an aversion to glucocorticoids. After failure of treatment with anakinra, an alternative option with the JAK-inhibitor tofacitinib was introduced because of the short half-life and to reduce glucocorticoid exposure. A switch to tofacitinib was only successful after an overlapping treatment with anakinra and tofacitinib for 3 weeks. The patient is currently being treated with monotherapy with tofacitinib as well as NSAID on demand, is in stable remission and can continue working as normal.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::9747a248d22599217aa6c56a6bdd2f79 https://pubmed.ncbi.nlm.nih.gov/32816071 Zobrazit plný text záznamu Full text from SpringerLink