| Autor: |
Xuejiao, Li, Huan, Du, Shenghua, Zhan, Wenting, Liu, Zhangyu, Wang, Jing, Lan, Longxiang, PuYang, Yuqiu, Wan, Qiuxia, Qu, Sining, Wang, Yang, Yang, Qin, Wang, Fang, Xie |
| Rok vydání: |
2021 |
| Předmět: |
|
| Zdroj: |
Frontiers in immunology. 13 |
| ISSN: |
1664-3224 |
| Popis: |
Accumulating evidence suggests that regulatory B cells (Bregs) play important roles in inhibiting the immune response in tumors. Programmed death 1 (PD-1) and programmed death ligand 1 (PD-L1) are important molecules that maintain the balance of the immune response and immune tolerance. This study aims to evaluate the soluble form of PD-L1 and its function in inducing the differentiation of B lymphocytes, investigate the relationship between soluble PD-L1 (sPD-L1) and B-cell subsets, and explore the antitumor activity of T lymphocytes after PD-L1 blockade in coculture systems. In an effort to explore the role of sPD-L1 in human breast cancer etiology, we examined the levels of sPD-L1 and interleukin-10 (IL-10) in the serum of breast tumor patients and the proportions of B cells, PD-1 |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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