| Autor: |
A R, Jones, W A, Bubb, S R, Murdoch, D A, Stevenson |
| Rok vydání: |
1986 |
| Předmět: |
|
| Zdroj: |
Australian journal of biological sciences. 39(4) |
| ISSN: |
0004-9417 |
| Popis: |
When boar spermatozoa were incubated with the (S)-isomer of the male antifertility agent alpha-chlorohydrin the activity of glyceraldehyde-3-phosphate dehydrogenase was inhibited. The (R)-isomer had no significant effect on the activity of this enzyme whereas (R,S)-3-chlorolactaldehyde caused an inhibition of its activity and also in that of lactate dehydrogenase. The in vitro production of (S)-3-chlorolactaldehyde, the active metabolite of (S)-alpha-chlorohydrin, was attempted by incubating boar spermatozoa with 1-chloro-3-hydroxypropanone. Preliminary results lead us to propose that this compound is converted into (S)-3-chlorolactaldehyde as well as to another metabolite which is an inhibitor of other enzymes within the fructolytic pathway. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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