Near-infrared spectroscopic determination of residual moisture in lyophilized sucrose through intact glass vials

Autor:	M S, Kamat, R A, Lodder, P P, DeLuca
Rok vydání:	1989
Předmět:	Sucrose Freeze Drying Spectrophotometry Infrared Water Glass Drug Packaging
Zdroj:	Pharmaceutical research. 6(11)
ISSN:	0724-8741
Popis:	A rapid, noninvasive, and nondestructive method for determining moisture in sealed freeze-drying vials is described. The method, based on near-infrared spectrometry, used a novel fiber-optic diffuse-reflectance probe to make remote reflectance measurements from 1100 to 2500 nm through the bottom of glass vials. The correlation of the method to results obtained by Karl Fischer analysis was good (r2 = 0.97). The moisture content of sucrose, a common cryoprotectant, was determined with an error of 0.27% using a single sample scan.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::96d325b88cf2bbe01d0fae856e951052 https://pubmed.ncbi.nlm.nih.gov/2594689 Zobrazit plný text záznamu Full text from SpringerLink