| Autor: |
M T, Dorigo, O, Cerin, G, Fracasso, R, Altafini |
| Rok vydání: |
1990 |
| Předmět: |
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| Zdroj: |
International journal of clinical pharmacology research. 10(3) |
| ISSN: |
0251-1649 |
| Popis: |
A double-blind cross-over study was carried out on 15 glaucoma patients so as to verify the effects of three the beta blockers, beta-1 selective betaxolol, non-selective timolol and befunolol an agent with intrinsic sympathomimetic activity on the heart rate, monitored by a Holter apparatus, and with the blood pressure measured in standing and supine positions before and after eight days of topical therapy. The results showed that timolol induced a significant decrease in minimum heart rate (-4.2 +/- 2.9) (p less than 0.001) and in diastolic blood pressure in standing position (-8.0 +/- 12.5 mmHg) (p less than 0.05), betaxolol decreased systolic pressure in orthostatism (-7.5 +/- 12.3 mmHg) and in clinostatism (-12.1 +/- 16.2 mmHg) and diastolic pressure in orthostatism (-6.25 +/- 9.4 mmHg) (p less than 0.05). Befunolol alone did not alter the heart rate or blood pressure. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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