The capacity of Th2 lymphocytes to deliver B-cell help requires expression of the transcription factor STAT3
| Autor: | Nathalie, Mari, Mélanie, Hercor, Sébastien, Denanglaire, Oberdan, Leo, Fabienne, Andris |
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| Rok vydání: | 2012 |
| Předmět: |
Mice
Knockout STAT3 Transcription Factor Transcriptional Activation B-Lymphocytes Mice Inbred BALB C Cell Communication Immunoglobulin E Lymphocyte Activation Immunoglobulin Class Switching Mice Inbred C57BL Mice Th2 Cells T-Lymphocyte Subsets Immunoglobulin G Animals STAT6 Transcription Factor Cells Cultured |
| Zdroj: | European journal of immunology. 43(6) |
| ISSN: | 1521-4141 |
| Popis: | CD4(+) T-cell help for B cells is crucial for effective Ab responses. Although follicular T helper (Tfh) cells have emerged as the main providers of T-cell help to B lymphocytes during the germinal center reaction, much less is known about the helper capacities of other effector CD4(+) T cells. The purpose of the present study was to evaluate the acquisition of B-cell help capacity of canonically derived T helper 2 (Th2) cells, a Th-cell subset originally considered responsible for B-cell help in vivo. We demonstrate herein that developing Th2 cells in mice co-express activated forms of signal transducer and activator of transcription 6 (STAT6) and STAT3 and that STAT3 expression was required for the capacity of Th2 cells to provide B-cell help. Thus, Th2 lymphocytes share a common, STAT3-mediated activation program for the acquisition of optimal B-cell help capacity with Tfh cells. Moreover, the expression of STAT3 in Th2 cells enhanced the IgG1-to-IgE class switch ratio in vivo, a finding with important implications for understanding the molecular basis of allergic diseases. |
| Databáze: | OpenAIRE |
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