Local cellular immune response in Helicobacter pylori associated type B gastritis--selective increase of CD4+ but not gamma delta T-cells in the immune response to H. pylori antigens
| Autor: | C, Seifarth, K, Deusch, K, Reich, M, Classen |
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| Rok vydání: | 1996 |
| Předmět: |
Adult
CD4-Positive T-Lymphocytes Male Antigens Bacterial Helicobacter pylori T-Lymphocytes Receptors Antigen T-Cell gamma-delta CD8-Positive T-Lymphocytes Cross Reactions Middle Aged Autoimmune Diseases Helicobacter Infections Immunoenzyme Techniques Gastric Mucosa Gastritis Pyloric Antrum Humans Female Lymphocyte Count Heat-Shock Proteins Aged |
| Zdroj: | Zeitschrift fur Gastroenterologie. 34(4) |
| ISSN: | 0044-2771 |
| Popis: | During recent years the infectious etiology of the majority of cases of chronic active type B gastritis and peptic ulcers has become increasingly evident. The chronicity of clinical symptoms and histopathological features such as numerous mucosal lymphocytic aggregates have implied a role of the specific cellular immune system. Whereas in Type A chronic active gastritis a pathogenetic role of lymphocytes and their target structures have been amply documented, in chronic active type B gastritis particularly that associated with Helicobacter pylori infection the nature of a specific immune response and its role in the pathogenesis of the epithelial and mucosal lesion has remained obscure. Here we report that CD4+ mucosal lymphocytes appear to selectively accumulate in Helicobacter pylori associated chronically active antral gastritis. Moreover, lamina propria gamma delta T lymphocytes were found to be more frequent in chronic active type B gastritis irrespective of the presence of absence of Helicobacter pylori. |
| Databáze: | OpenAIRE |
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