| Autor: |
E M, de Gussem, R J, Snijder, F J, Disch, P, Zanen, C J J, Westermann, J J, Mager |
| Rok vydání: |
2009 |
| Předmět: |
|
| Zdroj: |
Rhinology. 47(1) |
| ISSN: |
0300-0729 |
| Popis: |
Free O2- radicals may cause precapillary sphincter abnormalities, resulting in epistaxis in hemizygous knockout mice for Endoglin. The objective of this study was to test if antioxidants, like N-acetylcysteine (NAC), are have a role in the treatment of epistaxis in hereditary hemorrhagic telangiectasia (HHT).Forty-three patients participated in this study taking NAC 600 mg t.i.d for 12 weeks. Patients registered frequency, severity and duration of epistaxis and private and work-related quality of life (QOL), using a diary for two 6 weeks periods. The first period was prior to starting treatment and the second started after 6 weeks using NAC.There was a decrease infrequency (p0.01) and severity (p0.01) of epistaxis during the day. The improvement was most remarkable in male patients and patients with an ENDOGLIN mutation. In women and patients with an ALK-1 mutation, only a trend for improvement was found. Nocturnal epistaxis did not improve. The effect of epistaxis on the ability to work (p = 0.02) was reduced.This pilot study was conducted to investigate whether animal experiments can be translated to humans with HHT regarding epistaxis. The positive results with NAC are promising and justify a randomised clinical trial. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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