CYP2C8-Mediated Formation of a Human Disproportionate Metabolite of the Selective Na

Autor: Daigo, Asano, Syoya, Hamaue, Hamim, Zahir, Hideyuki, Shiozawa, Yumi, Nishiya, Takako, Kimura, Miho, Kazui, Naotoshi, Yamamura, Marie, Ikeguchi, Takahiro, Shibayama, Shin-Ichi, Inoue, Tsuyoshi, Shinozuka, Toshiyuki, Watanabe, Chizuko, Yahara, Nobuaki, Watanabe, Kouichi, Yoshinari
Rok vydání: 2021
Předmět:
Zdroj: Drug metabolism and disposition: the biological fate of chemicals. 50(3)
ISSN: 1521-009X
Popis: Predicting human disproportionate metabolites is difficult, especially when drugs undergo species-specific metabolism mediated by cytochrome P450s (P450s) and/or non-P450 enzymes. This study assessed human metabolites of DS-1971a, a potent Na
Databáze: OpenAIRE