In vitro antiviral activities of Chinese medicinal herbs against duck hepatitis B virus

Autor:	K T, Leung, Lawrence C M, Chiu, W S, Lam, Yaolan, Li, Samuel S M, Sun, Vincent E C, Ooi
Rok vydání:	2006
Předmět:	Ducks Plants Medicinal Hepatocytes Animals Antiviral Agents Cells Cultured Drugs Chinese Herbal Hepatitis B Virus Duck
Zdroj:	Phytotherapy research : PTR. 20(10)
ISSN:	0951-418X
Popis:	Fifty-six different Chinese medicinal herbs from 29 families were evaluated for their antiviral activities against duck hepatitis B virus (DHBV) in vitro. The DHBV DNA level in primary duck hepatocyte cultures was monitored by dot blot hybridization and the cytotoxicity was evaluated by MTT assay. Anti-DHBV activities were found more strongly in the aqueous extracts of Ardisia chinensis and Pithecellobium clypearia with selective indices of 2.6 and2.7, respectively, which were comparable to that of 2',3'-dideoxycytidine. Further research on the isolation of the active antiviral phytochemicals from these herbs may provide alternative options for the treatment of chronic hepatitis B.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::9613d95daf3622732dba2fa3b3331679 https://pubmed.ncbi.nlm.nih.gov/16892461 Zobrazit plný text záznamu Plný text