| Autor: |
L V, Kitaeva, I A, Mikhaĭlova, D, Semov, S N, Proshin, V Iu, Kravtsov |
| Rok vydání: |
2008 |
| Předmět: |
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| Zdroj: |
Tsitologiia. 50(2) |
| ISSN: |
0041-3771 |
| Popis: |
International Agency for Research on Cancer recognized as sufficient the evidence of Helicobacter pylori (HP) infection carcinogenicity and placed it into the 1 st group of carcinogens. Micronucleus level in gastric epithelial cells of antral stomach region of patients with chronic non-atrophy gastritis (n = 62) was studied. 40 patients of 62 had HP-associated gastritis. The HP-bacterium exists in a spiral and coccoid form. Both morphological forms were examined using immunocytochemistry. Significantly increased micronucleus number was observed in the cells of HP-infected patients compared with non-infected person (P0.05). The frequency of stomach epithelium cells with micronuclei was enhanced considerably in the patients infected with the coccoid HP form. Therefore the patients with HP-associated chronic gastritis caused by the coccoid form with high degree of colonization must be considered as a group of enhanced risk of gastric carcinogenesis. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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