| Autor: |
J L, Pico, O, Hartmann, D, Maraninchi, F, Beaujean, E, Benhamou, B, Mascret, G, Novakovitch, R, Ghalie, C, Kalifa, M, Hayat |
| Rok vydání: |
1986 |
| Předmět: |
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| Zdroj: |
Journal of the National Cancer Institute. 76(6) |
| ISSN: |
0027-8874 |
| Popis: |
Twenty-four poor-risk patients with acute lymphoblastic leukemia received a modified regimen of carmustine, cytarabine, cyclophosphamide, and 6-thioguanine (BACT) followed by autologous bone marrow transplantation (ABMT). Nineteen patients were in second or subsequent complete remission (CR) when treated with this regimen; 3 died early, 2 died of pneumonia in CR, 11 relapsed within 3 months (median), and 3 remain in CR with no maintenance therapy 14-24 months after ABMT. Of the 5 patients with measurable disease who were treated, 3 had CR and 1 remains in CR without maintenance therapy more than 28 months after ABMT. The toxicity of this regimen was acceptable, but late pulmonary toxic effects remain a major concern. These results are poor in terms of efficacy, and new effective methods of eradicating acute lymphoblastic leukemia in patients with poor prognosis should be investigated. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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