| Autor: |
V V, Naroev, I Z, Karlova, A N, Boĭko, O V, Zaĭtsev, E I, Gusev |
| Rok vydání: |
2004 |
| Předmět: |
|
| Zdroj: |
Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova. 104(9) |
| ISSN: |
1997-7298 |
| Popis: |
Multiple sclerosis (MS) is a severe organic disease of the central nervous system (CNS) affecting mostly young people. Optic neuritis (ON) is one of the first manifestations of the disease in approximately 75% of cases. The autoimmune reactions to myelin antigens play a key role in ON pathogenesis of MS. The pro- and anti-inflammatory unbalance is the most important factor of the origin, development and stabilization of CNS changes. Presented are the data on alterations of the levels of pro- and anti-inflammatory cytokines TNF-alpha, IF-gamma and antibodies to MBP and anti DNA in patient's tears. The clinical peculiarities of ON in MS correlating with immunological alterations are established. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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