| Autor: |
Jacqueline E, Lebenzon, Peter W, Denezis, Lamees, Mohammad, Katherine E, Mathers, Kurtis F, Turnbull, James F, Staples, Brent J, Sinclair |
| Rok vydání: |
2023 |
| Předmět: |
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| Zdroj: |
Proceedings of the National Academy of Sciences of the United States of America. 119(30) |
| ISSN: |
1091-6490 |
| Popis: |
Many insects enter a state of dormancy (diapause) during winter in which they lower their metabolism to save energy. Metabolic suppression is a hallmark of diapause, yet we know little about the mechanisms underpinning metabolic suppression in winter or how it is reversed in the spring. Here, we show that metabolic suppression in dormant Colorado potato beetles results from the breakdown of flight muscle mitochondria via mitophagy. Diapausing Colorado potato beetles suppress their metabolism by 90%, and this lowered metabolic rate coincides with a similar reduction in flight muscle mitochondrial function and density. During early diapause, beetles increase the expression of mitophagy-related transcripts ( |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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