| Autor: |
Greg, Coates, Bryan J, Ward, Clare, Bakewell, Andrew J P, White, Mark R, Crimmin |
| Rok vydání: |
2018 |
| Předmět: |
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| Zdroj: |
Chemistry (Weinheim an Der Bergstrasse, Germany) |
| ISSN: |
1521-3765 |
| Popis: |
sp3C−F Bonds of fluoroalkanes (7 examples; 1°, 2° and 3°) undergo addition to a low‐valent Mg−Mg species generating reactive organomagnesium reagents. Further reactions with a series of electrophiles results in a net C−F to C−B, C−Si, C−Sn or C−C bond transformation (11 examples, diversity). The new reactivity has been exploited in an unprecedented one‐pot magnesium‐mediated coupling of sp3C−F and sp2C−F bonds. Calculations suggest that the sp3C−F bond activation step occurs by frontside nucleophilic attack of the Mg−Mg reagent on the fluoroalkane. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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