| Autor: |
C, Pancharoen, S, Hongsiriwon, K, Swasdichai, T, Puthanakit, A, Tangsathapornpong, S, Lolekha, W, Punpanich, U, Tarunotai, B, Warachit, J, Mekmullica, P, Kosalaraksa, K, Chokephaibulkit, A, Kerdpanich |
| Rok vydání: |
2001 |
| Předmět: |
|
| Zdroj: |
The Southeast Asian journal of tropical medicine and public health. 31(4) |
| ISSN: |
0125-1562 |
| Popis: |
This study was conducted to elucidate the magnitude of problem and the clinical course of invasive meningococcal infection from 13 government hospitals in Thailand between 1994 and 1999. Thirty-six strains of Neisseria meningitidis were isolated from 16 blood and 24 cerebrospinal fluid specimens; 4 patients had positive culture in both blood and CSF. Of the 16 strains, 9 (56.3%) were serogroup B. Seventy-one and eighty-four percent of the isolates were susceptible to penicillin and cefotaxime/ceftriaxone respectively. Five out of six penicillin-nonsusceptible strains were found to be relatively resistant to penicillin with the MIC of 0.125 microg/ml. Of 33 patients whose medical records were available, 21 were males and 12 were females, with a mean age of 11.2 years. Fifteen patients (45.5%) presented with meningococcemia and 18 patients (54.5%) presented with meningococcal meningitis. Hypotension and purpura were found in 24.2% and 33.3% of patients respectively. The overall mortality rate was 9.1%. In conclusion, meningococcal disease is not common in Thailand, meningococcemia is a life-threatening condition whereas meningococcal meningitis is much less severe. The prevalence of meningococci relatively resistant to penicillin seems to be increasing. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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