| Autor: |
Qilin, Ma, Saidan, Zhang, Yanggen, Ning, Xiaoqun, Pu, Guolong, Yu, Zhaofen, Zheng, Xiaobin, Chen, Ke, Hu, Tianlun, Yang |
| Rok vydání: |
2009 |
| Předmět: |
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| Zdroj: |
Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences. 34(6) |
| ISSN: |
1672-7347 |
| Popis: |
To determine the effect of Tongxinluo on the endothelial function and hypersensitive C-reactive protein (hs-CRP) in acute coronary syndrome patients undergoing percutaneous coronary intervention(PCI).Thirty-three patients with unstable angina pectoris and 6 patients with acute myocardial infarction who underwent PCI for stenotic lesions of the coronary artery were enrolled. The patients were randomly assigned to a conventional group (n = 19) which took routine treatment or a tongxinluo group (n = 20) which took Tongxinluo(4 capsules once, 3 times per day) at the base of routine treatment after PCI. Nitric oxide synthase (NOS), nitric oxide (NO), endothelium-dependent vasodilation which was evaluated in the brachial artery flow mediated diameter(FMD) and hs-CRP were measured before the PCI and 24 hours and 3 months after the PCI. The correlation between NO and hs-CRP was analyzed.NOS, NO, and FMD in the 2 groups 24 hours after the PCI were significantly lower than those before the PCI(P0.05), but hs- CRP obviously increased (P0.05). NOS, NO, and FMD 3 months after the PCI in the 2 groups were significantly higher than those before the PCI (P0.05 or P0.01), but hs-CRP obviously decreased (P0.01).All indexes mentioned above in the Tongxinluo group showed greater changes than those of the conventional group(P0.05). NO was negatively correlated with hs-CRP (r = -0.3219, P0.01).Tongxinluo capsules have obvious beneficial effect on endothelial function and anti-inflammation in acute coronary syndrome patients undergoing PCI, by directly acting on the endothelium and indirectly inhibiting inflammation. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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