| Autor: |
B G, Durie, D, Hellman, J M, Woolfenden, R, O'Mara, M, Kartchner, S E, Salmon |
| Rok vydání: |
1981 |
| Předmět: |
|
| Zdroj: |
Cancer clinical trials. 4(1) |
| ISSN: |
0190-1206 |
| Popis: |
Eleven patients with high-risk thyroid carcinoma of anaplastic or mixed anaplastic-differentiated histology were treated using an early multimodality approach. Patients were classified using the prognostic index for thyroid carcinoma developed by the EORTC. Therapy consisted of a four-drug chemotherapy combination, radioiodine (131I), and Bacille-Calmette-Guerin (BCG) immunotherapy. Treatment was designed to maximize effects against both anaplastic and differentiated tumor components. There has been prolonged disease-free survival (14+ to 73+ months) in patients with clear cell, small cell, and mixed anaplastic histologies. Currently five patients have been in complete remission for over 4 years. Treatment has been well tolerated. The long-term participation in care by a multispecialty team has produced promising results which we hope can be valuable as a basis for multicenter trials. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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