Voxel-Based Dosimetry of Iron Oxide Nanoparticle-Conjugated
| Autor: | Arun, Gupta, Jae H, Shin, Min S, Lee, Ji Y, Park, Kyuwan, Kim, Joong H, Kim, Minseok, Suh, Cho R, Park, Young J, Kim, Myung G, Song, Jae M, Jeong, Dong S, Lee, Yun-Sang, Lee, Jae S, Lee |
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| Rok vydání: | 2019 |
| Předmět: |
Radioisotopes
Mice Inbred BALB C Single Photon Emission Computed Tomography Computed Tomography Tumor Protein Translationally-Controlled 1 Uterine Cervical Neoplasms Lutetium Ferric Compounds Xenograft Model Antitumor Assays Mice Folic Acid Tumor Cells Cultured Animals Humans Nanoparticles Female Radiopharmaceuticals Radiometry Algorithms |
| Zdroj: | Molecular pharmaceutics. 16(4) |
| ISSN: | 1543-8392 |
| Popis: | Several radiolabeled folic acid conjugates have been developed for targeted imaging and therapy. However, the therapeutic concept with radiolabeled folate conjugates has not yet been applied to clinical applications owing to the high renal absorbed dose. The effectiveness of targeted radionuclide therapy (TRT) depends primarily on the absorbed dose rate and on the total absorbed dose delivered to the tumor and to normal tissue. Owing to various limitations associated with organ level dosimetry, voxel-based dosimetry has become essential for the assessment of a more accurate absorbed dose during TRT. In this study, we synthesized iron oxide nanoparticle (IONP)-conjugated radiolabeled folate ( |
| Databáze: | OpenAIRE |
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