CD44
| Autor: | Dayang, Hui, Jianning, Chen, Ye, Jiang, Yuhang, Pan, Zhigang, Zhang, Min, Dong, Chunkui, Shao |
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| Rok vydání: | 2019 |
| Předmět: |
Adult
Male Epstein-Barr Virus Infections Herpesvirus 4 Human Epithelial-Mesenchymal Transition Mice SCID T-Lymphocytes Regulatory Dinoprostone Mice Cell Movement Mice Inbred NOD Stomach Neoplasms Cell Line Tumor Spheroids Cellular Animals Humans Aged Cell Proliferation Carcinoma CD24 Antigen Middle Aged Xenograft Model Antitumor Assays Gene Expression Regulation Neoplastic Hyaluronan Receptors Female Signal Transduction |
| Zdroj: | Experimental cell research. 390(2) |
| ISSN: | 1090-2422 |
| Popis: | EBV-associated gastric carcinoma (EBVaGC) is accompanied by massive lymphocyte infiltration, but therapy resistance and tumor progression still occur in patients with EBVaGC. Cancer stem cells (CSCs) are reported to possess immunomodulatory ability that allows them to resist immune-mediated rejection for many tumor types. However, whether and how CSCs in EBVaGC exhibit immunosuppression has not yet been elucidated. We isolated CSC-like sphere-forming cells (SFCs) from EBVaGC cell line SNU-719 using the cancer sphere method. We validated their CSC-associated properties in the expression of the epithelial-mesenchymal transition (EMT)-related genes, the ability to form colonies, and resistance to chemotherapy drug-induced apoptosis and explored their immunomodulatory ability using the coculture system with PBMC (peripheral blood mononuclear cell). These CSC-like SFCs were CD44 |
| Databáze: | OpenAIRE |
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