| Popis: |
To investigate the effect of glucagon-like peptide 1 (GLP-1) on cognitive dysfunction in diabetic rats.Male SD rats were randomly divided into normal control group, diabetes mellitus (DM) group, and GLP-1 treatment group. Rat models of type 2 diabetes were established by high-sugar and high-fat feeding and streptozotocin (STZ) injection, and 25 days after the onset of diabetes, GLP-1 was infused in GLP-1 treatment group at the rate of 30 pmol·kgCompared with the normal control group, the diabetic rats showed significantly decreased learning and memory abilities (P0.05) with increased hippocampal expressions of APP, BACE1, Arc, ERK1/2, PKA, and PKC mRNAs (P0.05) and Arc protein. Compared with diabetic rats, GLP-1-treated rats showed significantly improvements in the learning and memory function (P0.05) with decreased expressions of APP, BACE1, Arc, ERK1/2, and PKA mRNAs (P0.05) and Arc protein.GLP-1 can improve cognitive dysfunctions in diabetic rats possibly by regulating the PKC, PKA, and ERK1/2 pathways and inhibiting Arc expression in the hippocampus. |
