TNF-alpha and homocysteine levels in type 1 diabetes mellitus

Autor:	M T, Abdel Aziz, H H, Fouad, G A, Mohsen, M, Mansour, S, Abdel Ghaffar
Rok vydání:	2004
Předmět:	Glycated Hemoglobin Male Time Factors Adolescent Tumor Necrosis Factor-alpha Hyperhomocysteinemia Apoptosis Cholesterol LDL Islets of Langerhans Cholesterol Diabetes Mellitus Type 1 Diabetic Neuropathies Case-Control Studies Albuminuria Humans Egypt Female Homocysteine Diabetic Angiopathies
Zdroj:	Eastern Mediterranean health journal = La revue de sante de la Mediterranee orientale = al-Majallah al-sihhiyah li-sharq al-mutawassit. 7(4-5)
ISSN:	1020-3397
Popis:	The role of homocysteine as an independent risk factor for vascular endothelial damage, and the possible link between homocysteine and tumour necrosis factor-alpha (TNF-alpha) as two synergistic risk factors for beta-cell apoptosis in type 1 diabetes mellitus was studied. Plasma homocysteine levels were significantly elevated in all diabetic patients compared with controls and diabetic patients with vascular complications showed higher elevations. Furthermore, homocysteine levels showed significant positive correlation with the degree of microalbuminuria. TNF-alpha levels were elevated in all diabetic patients compared with controls. These results may have therapeutic implications.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::9555672adddcd3521aedac14eca6abaf https://pubmed.ncbi.nlm.nih.gov/15332766 Zobrazit plný text záznamu