| Autor: |
Alexandre, de la Taille, Marc, Zerbib, Sophie, Conquy, Delphine, Amsellem-Ouazana, Djillali, Saighi, Bernard, Debré |
| Jazyk: |
francouzština |
| Rok vydání: |
2002 |
| Předmět: |
|
| Zdroj: |
Progres en urologie : journal de l'Association francaise d'urologie et de la Societe francaise d'urologie. 12(2) |
| ISSN: |
1166-7087 |
| Popis: |
Study of the efficacy of intermittent endocrine therapy after failure of local treatment.74 patients were treated for biochemical recurrence after radical prostatectomy (n = 30), radiotherapy (n = 28) or radical prostatectomy followed by radiotherapy (n = 16). Treatment (63 patients were treated by antiandrogens alone, 8 by LHRH analogue and 3 by complete androgen suppression) was continued for 6 months after obtaining undetectable PSA levels for patients after radical prostatectomy (and restarted when PSA4 ng/ml) or a PSA nadir4 ng/ml for the other patients (and restarted for PSA10 ng/ml).The duration of periods without treatment represented 50% of the total treatment cycle. With a mean follow-up of 43.8 months, the overall 5-year biochemical progression-free survival rate was 54.6%. On multivariate analysis, factors predictive of biochemical progression were age less than 70 years (p = 0.05), Gleason score greater than or equal to 8 (p = 0.038) and the presence of lymph node metastases (p = 0.05).Intermittent endocrine therapy is a treatment option for patients with recurrence after local treatment. Candidates for intermittent endocrine therapy must be over the age of 70, with localized adenocarcinoma and a Gleason score less than or equal to 7. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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