[Malignant atrophic papulosis (Köhlmeier-Degos disease). Failure to respond to interferon alpha-2a, pentoxifylline and aspirin]
| Autor: | B, Melnik, H, Hariry, F, Vakilzadeh, C, Gropp, G, Sitzer |
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| Jazyk: | němčina |
| Rok vydání: | 2002 |
| Předmět: |
Slow Virus Diseases
Aspirin Skin Diseases Papulosquamous Interferon-alpha Thrombosis Interferon alpha-2 Middle Aged Skin Diseases Vascular Recombinant Proteins Diagnosis Differential Connective Tissue Disease Progression Humans Drug Therapy Combination Female Treatment Failure Atrophy Pentoxifylline Skin |
| Zdroj: | Der Hautarzt; Zeitschrift fur Dermatologie, Venerologie, und verwandte Gebiete. 53(9) |
| ISSN: | 0017-8470 |
| Popis: | A 45 year old female patient presented with the cutaneous manifestations of malignant atrophic papulosis (Köhlmeier-Degos disease) for two years. The typical papules with central porcelain-white atrophy correspond histologically to wedge-shaped necrosis of the connective tissue due to thrombotic occlusion of small vessels in the corium. The pathogenesis of malignant atrophic papulosis and effective treatment modalities are unknown. A slow virus infection has been suggested by some authors. Therefore, we attempted an immune therapy with interferon alpha-2a over a period of 11 months, but failed to cause a significant effect on the appearance and progression of the skin lesions. Furthermore, we could not confirm the effectiveness of a recently reported treatment modality with pentoxifylline and aspirin administered to our patient over a period of 5 months. |
| Databáze: | OpenAIRE |
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