| Autor: |
Juan Manuel, Díez Piña, María Jesús, Fernández Aceñero, María Jesús, Llorente Alonso, Salvador, Díaz Lobato, Sagrario, Mayoralas Alises, Esteban, Pérez Rodríguez, Dolores, Alvaro Álvarez, Asunción, Flórez Horcajada, Raquel, Pérez Rojo |
| Rok vydání: |
2011 |
| Předmět: |
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| Zdroj: |
Medicina clinica. 139(2) |
| ISSN: |
1578-8989 |
| Popis: |
Smoking creates an inflammation that leads to lose of lung function. Tumor necrosis factor alpha (TNF-α) is a cytokine that plays an important role in the pathogenesis of chronic obstructive pulmonary disease. There is a need to develop methods for an early detection of an impaired lung function in smokers. We aimed to show that smokers have higher levels of TNF-α in serum and exhaled breath condensate (EBC). We also analysed the influence of sex, age and weight on TNF-α, and determined the association between smoking, pulmonary function and TNF-α.Prospective study of smokers and non-smokers without any known disease. Respiratory function tests, EBC and blood samples were performed before smoking cessation.SPSS 11.0.Fifty-one patients (60.8% smokers), 56.9% females, mean age 39.88 years old. Smokers initiated at an age of 15.77 years; the mean of cigarettes/day was 21.68. Significant differences in TNF-α serum levels between smokers and non-smokers were observed (P.043). Differences did not reach significance for EBC. For tobacco consumption data, only age at smoking initiation and serum TNF-α levels had a correlation. A significant relation between TNF-α serum levels and forced expiratory volume in one second and forced vital capacity was found.Smokers show higher TNF-α levels in serum. Number of years of smoking has an influence on TNF-α levels. There is a modest correlation between pulmonary function and plasma TNF-α levels, but not for EBC. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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