Longan (Dimocarpus longan Lour.) Aril ameliorates cognitive impairment in AD mice induced by combination of D-gal/AlCl
| Autor: | Hongyan, Li, Tianrong, Lei, Jianghua, Zhang, Yuhui, Yan, Nan, Wang, Cheng, Song, Chang, Li, Mingyu, Sun, Jinyu, Li, Yuxin, Guo, Jingxian, Yang, Tingguo, Kang |
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| Rok vydání: | 2020 |
| Předmět: |
Mitogen-Activated Protein Kinase Kinases
Behavior Animal Plant Extracts Brain Apoptosis Galactosamine Disease Models Animal Mice Oxidative Stress Cognition Sapindaceae Alzheimer Disease ras Proteins Aluminum Chloride Animals Cognitive Dysfunction Female Phosphorylation Extracellular Signal-Regulated MAP Kinases Maze Learning Nootropic Agents Signal Transduction |
| Zdroj: | Journal of ethnopharmacology. 267 |
| ISSN: | 1872-7573 |
| Popis: | According to the theory of traditional Chinese medicine (TCM), Alzheimer's disease (AD) is identified as "forgetfulness" or "dementia", and it can be caused by spleen deficiency. Longan Aril (the aril of Dimocarpus longan Lour., LA) is a kind of Chinese medicine, and it can improve intelligence attributed to entering the spleen-meridian. This study aimed to explore the therapeutic effects of LA on AD mice with spleen deficiency, and to understand anti-AD mechanism of LA.A mouse model of AD with spleen deficiency was established by D-gal (140 mg/kg, intraperitoneal injection) and AlClLA improved learning and memory abilities, superoxide dismutase (SOD) level, and form and number of Nissl bodies, while reduced the levels of AβLA could improve the cognitive ability and reduce the pathologic impairment in AD mice, which might be partly mediated via inhibition of RAS/MEK/ERK singling pathway. |
| Databáze: | OpenAIRE |
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