| Autor: |
Sutatip, Pongcharoen, Pannika Niumsup, Ritvirool, Donruedee, Sanguansermsri, Pairat, Chanchan, Poj, Jienmongkol, Puntharee, Butkhamchot, Prateep, Warnnissorn, Napatawn, Banchuin, Stitaya, Sirisinha |
| Rok vydání: |
2008 |
| Předmět: |
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| Zdroj: |
Asian Pacific journal of allergy and immunology. 26(1) |
| ISSN: |
0125-877X |
| Popis: |
Burkholderia pseudomallei is the causative agent of melioidosis. One of the main risk factors for B. pseudomallei infection in endemic areas is diabetes mellitus. The present study investigated IL-17 mRNA and protein expression by peripheral blood mononuclear cells in response to B. pseudomallei infection in 10 diabetic patients in comparison to 10 healthy blood donors. The IL-17 expression in diabetic patients was significantly lower (p0.05) than in the controls. However, IL-23 mRNA expression of the 2 groups was comparable. The present findings suggest that melioidosis affects T cell IL-17 production and that patients with diabetes mellitus have a defective IL-17 production in response to this type of infection. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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