Effect of chronic intrarenal prostaglandin E2 infusion and angiotensin II blockade on arterial pressure in the dog

Autor:	G M, Hockel, A W, Cowley
Rok vydání:	1980
Předmět:	Captopril Dogs Proline Angiotensin II Prostaglandins E Osmolar Concentration Renin Sodium Animals Blood Pressure Infusions Parenteral Urine
Zdroj:	Advances in prostaglandin and thromboxane research. 7
ISSN:	0361-5952
Popis:	The present investigation demonstrates that chronic intrarenal PGE2 infusion results in a PRA-induced increase in arterial pressure. This conclusion is supported by an 8-fold rise in PRA and the marked reduction of arterial pressure during saralasin and CEI infusion. If the chronic effects of endogenously released PGE2 are similar to arterial administration, then the net effect of chronically elevated renal PGE2 in the dog appears to be a moderate, sustained hypertension.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::94b1fdb4d1e17553720f820a9b17d6ad https://pubmed.ncbi.nlm.nih.gov/6989177 Zobrazit plný text záznamu