In vivo EPR pharmacokinetic evaluation of the redox status and the blood brain barrier permeability in the SOD1

Autor:	Stefan, Stamenković, Aleksandra, Pavićević, Miloš, Mojović, Ana, Popović-Bijelić, Vesna, Selaković, Pavle, Andjus, Goran, Bačić
Rok vydání:	2017
Předmět:	Amyotrophic Lateral Sclerosis Electron Spin Resonance Spectroscopy Brain Rats Cyclic N-Oxides Disease Models Animal Superoxide Dismutase-1 Blood-Brain Barrier Mutation Disease Progression Animals Humans Spin Labels Rats Transgenic Reactive Oxygen Species Oxidation-Reduction
Zdroj:	Free radical biologymedicine. 108
ISSN:	1873-4596
Popis:	Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disorder affecting the motor pathways of the central nervous system. Although a number of pathophysiological mechanisms have been described in the disease, post mortem and animal model studies indicate blood-brain barrier (BBB) disruption and elevated production of reactive oxygen species as major contributors to disease pathology. In this study, the BBB permeability and the brain tissue redox status of the SOD1
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::94a436420f4a8a31fe9689a0aa5b5e17 https://pubmed.ncbi.nlm.nih.gov/28366802 Zobrazit plný text záznamu Full Text from ScienceDirect