| Autor: |
Ningbo, Cui, Rong, Fu, Wen, Qu, Erbao, Ruan, Xiaoming, Wang, Guojin, Wang, Yuhong, Wu, Hong, Liu, Jing, Guan, Jia, Song, Limin, Xing, Lijuan, Li, Huijuan, Jiang, Hui, Liu, Yihao, Wang, Chunyan, Liu, Wei, Zhang, Huaquan, Wang, Zonghong, Shao |
| Rok vydání: |
2015 |
| Předmět: |
|
| Zdroj: |
Zhonghua yi xue za zhi. 95(32) |
| ISSN: |
0376-2491 |
| Popis: |
To investigate the clinical characteristics and risk factors of monosomy 7 malignant clonal evolution in patients with severe aplastic anemia (SAA) treated with combined immunosuppressive therapy (IST).The clinical data of SAA patients treated with IST who had monosomy 7 malignant clonal evolution from October 2004 to January 2012 were analyzed respectively.Six patients (4.2%) had monosomy 7 clonal evolutions. The median time to monosomy 7 was 36 (12-75) months after IST. All 6 patients were diagnosed myelodysplastic syndromes (MDS). Among them, 3 patients transformed to acute myeloid leukemia following MDS. The time was 24, 45 and 51 months after IST. The median following time was 42 (17-84) months. Four patients died during the following time. The median time from MDS to death was 9 (5-17) months. Among them, three patients died with infection, one died with cerebral hemorrhage. Six patients had the clinical characteristics that they had no response to IST after 6 months, high monocyte percentage in one month after IST combined with recombinant human granulocyte colony stimulating factor (rHu-GCSF) and agranulocytosis in 3 months after IST.Poor myeloid response to IST suggests malignant clonal hematopoiesis and poor prognosis in SAA patients. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
|
