Changes in hemostatic factors after kidney transplantation
| Autor: | Jun, Kang Woong, Cho, Jinbeom, Kim, Mi Hyeong, Hwang, Jeong Kye, Park, Sun Cheol, Moon, In Sung, Kim, Ji Il |
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| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
hemostatic factors
Adult Graft Rejection Male Observational Study kidney transplantation Middle Aged Hemostatics Cohort Studies Postoperative Complications Republic of Korea Electronic Health Records Humans Kidney Failure Chronic Female end stage renal disease chronic kidney disease Research Article Retrospective Studies |
| Zdroj: | Medicine |
| ISSN: | 1536-5964 0025-7974 |
| Popis: | Chronic kidney disease affects hemostasis in complex ways, producing both thrombotic and hemorrhagic diatheses. These changes may impact patient morbidity and mortality pre-transplantation, as well as allograft survival after kidney transplantation (KT). This study was conducted to analyze changes in hemostatic factors in the early post-KT period. We retrospectively analyzed 676 recipients of kidney allografts from December 2009 to December 2014. Patients receiving plasmapheresis pre- or post-KT, experiencing early allograft failure, or receiving anticoagulants or antiplatelet agents pre- or post-KT were excluded. Of the 367 included patients, acute (≤1 month) rejection occurred in 4.1% and delayed graft function occurred in 3.3%. Postoperative bleeding complications occurred in 7.9% of patients and thrombotic complications in 3.3%. Pre-transplantation, recipients had below normal hemoglobin, above normal d-dimer and homocysteine levels, and elevated rates of antiphospholipid antibodies. Hemoglobin increased to almost normal by postoperative day (POD) 28 (P |
| Databáze: | OpenAIRE |
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