Cardioprotection by nifedipine cardioplegia during coronary artery surgery
| Autor: | W, Trubel, W, Zwoelfer, A, Moritz, A, Laczkovics, W, Haider |
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| Rok vydání: | 1994 |
| Předmět: |
Male
Nifedipine Cardiac Output Low Hemodynamics Myocardial Ischemia Arrhythmias Cardiac Heart Middle Aged Sodium Chloride Potassium Chloride Isoenzymes Placebos Bicarbonates Calcium Chloride Double-Blind Method Heart Arrest Induced Humans Female Magnesium Cardiac Output Coronary Artery Bypass Cardioplegic Solutions Creatine Kinase |
| Zdroj: | European journal of anaesthesiology. 11(2) |
| ISSN: | 0265-0215 |
| Popis: | In a double-blind, placebo-controlled, randomized clinical study, the cardioprotective effect of nifedipine (Adalat, Bayer) as an adjunct to St. Thomas' cardioplegia was investigated in 24 patients undergoing coronary artery bypass grafting. Nifedipine at a dosage of 200 micrograms or placebo was added to each 1000 ml of St. Thomas solution, under strict light protection. ECG and haemodynamic data, including cardiac output measurements, serum calcium levels, creatine phosphokinase, (CK) CK-MB and lactate were measured during and after the operation. Additional cardioprotective effects were demonstrated in the nifedipine group by a significantly lesser reduction of the cardiac index after cardiopulmonary bypass and lower post-operative CK and CK-MB serum levels (P0.05). The incidence of ischaemia and cardiac arrhythmias was significantly higher in the placebo group on the post-operative ECG. |
| Databáze: | OpenAIRE |
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