Mussel-inspired antimicrobial gelatin/chitosan tissue adhesive rapidly activated in situ by H
| Autor: | Xin Ye, He, Ao, Sun, Tao, Li, Yong Jun, Qian, Hong, Qian, Yun Fei, Ling, Ling Hong, Zhang, Qing Ya, Liu, Tao, Peng, Zhiyong, Qian |
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| Rok vydání: | 2020 |
| Předmět: |
Chitosan
Staphylococcus aureus Wound Healing Catechols Hydrogels Ascorbic Acid Hydrogen Peroxide Sutureless Surgical Procedures Anti-Bacterial Agents Bivalvia Body Temperature Injections Rats Sprague-Dawley Mice Pseudomonas aeruginosa NIH 3T3 Cells Wound Infection Animals Gelatin Methacrylates Tissue Adhesives |
| Zdroj: | Carbohydrate polymers. 247 |
| ISSN: | 1879-1344 |
| Popis: | The development of minimally invasive surgery has created a demand for ideal medical adhesives exhibiting biocompatibility, biodegradability, antimicrobial activity, and strong adhesion to tissues in wet environments. However, as clinically approved surgical tissue glues suffer from poor adhesion activation, limited adhesion strength, and toxicity, novel tissue glues are highly sought after. Herein, a mussel-inspired injectable hydrogel was prepared from catechol- and methacrylate-modified chitosan/gelatin and shown to exhibit biocompatibility, inherent antimicrobial activity, and good adhesion to wet tissues. Moreover, as this gel could be applied onto tissue surfaces and cured in situ within seconds of body contact by a biocompatible and multifunctional redox initiator (H |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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